题目英文：Profilesofimmunecellinfiltrationandimmune-relatedgenesinthetumormicroenvironmentofcolorectalcancer
题目中文：大肠癌肿瘤微环境中免疫细胞浸润及免疫相关基因的研究
发表时间：年7月15日杂志：BiomedicinePharmacotherapy影响因子：4.
摘要英文：
Purpose:tumor-infiltratingimmunecellsarehighlyrelevanttotheprogressionandprognosisofcolorectalcancer(CRC).Theaimofthisstudyistoexploretheimmunecellsandimmune-relatedgeneexpressionintumormicroenvironmentofCRC.
Methods:CIBERSORT,adeconvolutionalgorithm,wasusedtoanalyzetheinfiltrationof22immunecelltypesinthetumormicroenvironmentandimmune-relatedgeneexpressioninCRCand40adjacentnon-tumoroustissues.
Results:awideheterogeneityofimmunecellsamongdifferentpairedtissuesandintumorstageswasuncovered.M0macrophages,M1macrophagesandCD4memoryactivatedTcellswereinfiltratedsignificantlymoreinCRC