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大肠癌肿瘤微环境中免疫细胞浸润及免疫相关 [复制链接]

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题目英文:Profilesofimmunecellinfiltrationandimmune-relatedgenesinthetumormicroenvironmentofcolorectalcancer

题目中文:大肠癌肿瘤微环境中免疫细胞浸润及免疫相关基因的研究

发表时间:年7月15日杂志:BiomedicinePharmacotherapy影响因子:4.

摘要英文:

Purpose:tumor-infiltratingimmunecellsarehighlyrelevanttotheprogressionandprognosisofcolorectalcancer(CRC).Theaimofthisstudyistoexploretheimmunecellsandimmune-relatedgeneexpressionintumormicroenvironmentofCRC.

Methods:CIBERSORT,adeconvolutionalgorithm,wasusedtoanalyzetheinfiltrationof22immunecelltypesinthetumormicroenvironmentandimmune-relatedgeneexpressioninCRCand40adjacentnon-tumoroustissues.

Results:awideheterogeneityofimmunecellsamongdifferentpairedtissuesandintumorstageswasuncovered.M0macrophages,M1macrophagesandCD4memoryactivatedTcellswereinfiltratedsignificantlymoreinCRC

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