淋巴肉瘤

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TUhjnbcbe - 2021/8/26 17:17:00
胃肠道、肝胆胰肿瘤

食管肿瘤

1.Barrett’s食管阳性:CK20,MUCs,CDX2,P.鳞状细胞癌(普通型)阳性:CAM5.2,AE1/AE3,CK5/6,34βE12,CK14,P63(部分),CK19阴性:CK7,CK20,WT-1,CD5,TTF-13.基底细胞样鳞癌阳性:Bcl-2,CK5/6,CK13,CK14,CK19,P63,S-阴性:CAM5.2,AE1/AE34.腺癌阳性:CK7,CK20阴性:P.腺样囊性癌阳性:CAM5.2,AE1/AE3,CD(导管分化细胞)34βE12,CEA(肌上皮分化细胞)S-,SMA,vimentin,P63阴性:CgA,Syn6.黏液表皮样癌阳性:(鳞状上皮样区域)34βE12,CK14,P63(腺上皮区域)CK7,CEA7.梭形细胞分化癌或肉瘤样癌阳性:CAM5.2,AE1/AE3,vimentin阴性:desmin8.平滑肌瘤阳性:SMA,desmin,MSA,calponin阴性:CD34,CD,S-9.平滑肌肉瘤阳性:SMA,desmin,vimentin阴性:CD34,CD10.胃肠道间质瘤阳性:CD34,CD,PDGFRA,DOG1,PKCθ11.神经内分泌肿瘤阳性:Syn,CgA,NSE,TTF-1,CD56阴性:CK19,CK20,34βE.横纹肌肉瘤13.滑膜肉瘤14.Kaposi肉瘤阳性:CD31,CD.颗粒细胞瘤阳性:S-,CD57,vimentin阴性:desmin,CD34,CD,CAM5.2,EMA,CEA16.恶性黑色素瘤阳性:vimentin,S-,HMB45,MART/melan-A,tyrosinase阴性:CK,CEA17.淋巴瘤(大B细胞淋巴瘤和MALT淋巴瘤多见)胃部肿瘤1.胃腺癌阳性:CAM5.2,Pan-CK,CK7,CK20,CK18,CK19,CDX2,CEA(部分),villin(部分),Her-2阴性:CK5/6,vimentin,P63(鳞化区域可阳性),TTF-1,CA(少量)2.含神经内分泌分化的腺癌阳性:CKs,CgA,Syn阴性:CD.印戒细胞癌阳性:CDX2,CK20,CEA阴性:GCDFP-15,ER4.高分化神经内分泌肿瘤或小细胞癌阳性:CgA,Syn,CDX2阴性:CK20,TTF-1,CK5/65.肉瘤样癌6.胃肠道间质瘤阳性:CD,CD34,CD99,SMA,HHF-35(25%-50%),CK18(10%)阴性:Syn(5%),desmin(2%),CgA,S-7.神经鞘瘤阳性:S-,CD57(Leu7),GFAP阴性:CD,CD34,SMA8.纤维瘤病阳性:vimentin,desmin,β-catenin阴性:CD,CD34(少量细胞可阳性)9.孤立性纤维瘤阳性:CD34,CD99,SMA,Bcl-2阴性:CD10.肝样腺癌阳性:AFP,Hepatocyte11.绒毛膜癌阳性:β-hCG,PLAP小肠肿瘤1.神经内分泌肿瘤阳性:CgA,Syn,CD57,villin,CEA,CDX2,CK20(25%),somatostatin阴性:CK7,TTF-12.GIST阳性:CD,CD34,Bcl-2,SMA,S-(20%)阴性:desmin,CgA3.远端小肠腺癌(表型类似结肠癌)阳性:CK18,CK19,CK20,CDX2,villin,MUC1,MUC5AC(33%)阴性:CK7,CK5/6,P63,vimentin4.壶腹部腺癌(表型类似胰胆管腺癌)阳性:CK18,CK19,CK7(50%),CK20(50%),CDX2,MUC1,MUC5AC(33%)阴性:CK5/6,P63,vimentin阑尾肿瘤1.神经内分泌肿瘤阳性:CgA,Syn,E-cadherin,β-catenin,CK20,CDX2阴性:CEA,CK72.不产生黏液的腺瘤及腺癌阳性:CK20,CK73.产生黏液的腺瘤及腺癌阳性:CK8,CK18,CK19,CK20,CDX2,villin,MUC2,MUC5A,MUC1(20%)结直肠肿瘤1.神经鞘瘤阳性:S-,GFAP,CD34阴性:CD2.神经纤维瘤阳性:S-,neurofilament阴性:CD3.GIST阳性:CD,CD34,CD99,SMA阴性:GFAP,desmin,S-,neurofilament4.平滑肌瘤阳性:SMA,MSA,desmin阴性:CD,CD34,S-5.神经内分泌肿瘤(右半结肠)阳性:serotonin,CgA,Syn,CK20(50%),CK7(25%)阴性:S-,TTF-1(直乙结肠)阳性:CgA,Syn,PAP(少数)阴性:S-,PSA,PS6.腺癌阳性:CK20,CDX2,villin,MUC1,MUC2,S-(20%),PLAP(部分,膜阳性),CA阴性:CK7(5%可阳性),CgA,Syn,MUC5A,CK5/6,GCDF-15,TTF-1,HPC7.高分化神经内分泌肿瘤阳性:Syn,低分子量CK,CAM5.2,35βH11(含有非角化鳞癌成分)34βE12,CK5/6,P63阴性:CK20,CgA,CD57,CD8.肉瘤样癌肛管肿瘤1.鳞状细胞癌及其亚型2.腺癌阳性:CK7阴性:CK.Paget’s病阳性:AE1/AE3,CK7,CK20(部分),CEA,GCDFP-15阴性:34βE12,S-胰腺肿瘤1.胰腺神经内分泌肿瘤阳性:PGP9.5,CgA,Syn,CK8,CK18,CAM5.2,AE1/AE3(部分)阴性:CK7,CK20,TTF-1,CDX2,HepPar1,Villin2.低分化神经内分泌癌阳性:CD56,CD57,CgA,Syn,calcitonin3.导管内乳头状黏液性肿瘤阳性:CK7,CDX2,MUC2,MUC5AC,DUPAN-2,CA19-9,hMLH1,hMLH2,hMLH6阴性:CK20,CEA4.黏液性囊性肿瘤阳性:CK7,CK20,CA,CA19-9,MUC5A,Smad4(卵巢样间质区域)vimentin,SMA,MSA,ER(20%-80%),α-inhibin阴性:MUC1,MUC25.浆液性囊腺瘤阳性:AE1/AE3,EMA,MUC1,MUC6,CA19-9阴性:CEA,CgA,Syn6.导管腺癌阳性:EMA,CAM5.2,CA19-9,CK19,CK7,CK20,MUC1,MUC4,MUC5A,CDX2,Smad4,CD5,CD7,mesothelin部分阳性:CgA,Syn,CA,villin,CK5/6阴性:AFP,PAP,PSA,WT-1,TTF-1,MUC2,HPC,vimentin,ER,PR7.浸润性黏液性腺癌阳性:MUC2阴性:CA,MUC18.含破骨样巨细胞的未分化癌阳性:pan-CK,vimentin,AE1/AE3,CAM5.2,35βH11,CK8,CK18,CK19(破骨样巨细胞)CD68,LCA,CD71,α-1-antichymotrypsin阴性:EMA,CEA,HMB45,MART-19.腺泡细胞癌阳性:AE1/AE3,CAM5.2,CK7,CK8,CK19,trypsin,α-1-antichymotrypsin,Syn(10%-50%)阴性:CEA,CgA,vimentin,AFP10.实性假乳头状瘤阳性:α-1-antichymotrypsin,vimentin,β-catenin(部分表达)CK20,AE1/AE3,CAM5.2,CK7,CD10,Syn,ER,PR阴性:EMA,CEA,AFP,CA19-9,S-11.血管周上皮样细胞瘤阳性:actin,HMB45,Myo-D1阴性:CD,CD34,SMA,AE1/AE3,CAM5.2,CgA,Syn肝及胆管肿瘤1.胆汁性肝硬化及硬化性胆管炎阳性:(小胆管上皮)CK7,CK19,CD31/CD.肝细胞腺瘤阳性:CK8,CK18,HPC阴性:CK7,CK19,CK20,CA19-9,34βE.胆管错构瘤及腺瘤阳性:CK7,CK19阴性:CK20,MUC1,CEA4.肝母细胞瘤阳性:AFP,CgA,CKs,vimentin5.普通型肝细胞癌阳性:CK8,CK18,CAM5.2,OSCAR,AFP(高级别肝细胞癌阴性),HPC,AE1/AE3(少数),CD56(弱),CD31/34(内皮细胞),EMA,CEA(胆管型)阴性:CK7(少数阳性),CK20(20%阳性),CK17,CA19-9,Calretinin,α-inhibin,TTF-1,CgA,Syn,MART-1,CK5/6,ER6.具有胆管分化的肝细胞癌阳性:AE1/AE3,CK7,CK19,CEA7.梭形细胞肝细胞癌阳性:vimentin,CAM5.2,HPC阴性:AFP8.纤维板层型肝细胞癌阳性:CK8,CK18,CAM5.2,HPC,CK7,AFP(20%),α-1-antichymotrypsin9.胆管癌阳性:CK7,CK8,CK18,CK19,CAM5.2,CA19-9,CEA,MOC-31,CDX2(75%),CK17(50%),CK20(20%)阴性:HPC,AFP,Syn,GCDFP-.梭形细胞胆管癌或肉瘤样癌阳性:vimentin,CEA,低分子量角蛋白(CAM5.2,AE1/AE3,EMA)阴性:AFP,S-11.混合性肝细胞-胆管癌12.低分化/未分化癌阳性:CK7,CK19阴性:CEA,CA19-9,AFP,HPC13.胆管囊腺瘤或癌阳性:AE1/AE3,CA19-9,CEA,CK7,CK20,CA,vimentin,SMA,desmin14.神经内分泌肿瘤(低级别及高级别)

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